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      S80008

      Sodium picosulfate

      MedMol 99%
      • 英文名:
      • Sodium picosulfate
      • 別名:
      • 匹克硫酸鈉;4,4'-(吡啶-2-基亞甲基)雙苯基雙硫酸酯鈉鹽;吡苯氧磺鈉;匹可硫酸鈉;匹可硫酸鈉(匹可速發);匹可硫酸鈉(匹克硫酸鈉);比沙可啶雜質D;比沙可定雜質D;4,4'-(pyridin-2-ylmethylene)bisphenyl bis (sodiumsulphate);sodium picosulfate;Disodium bis[4-[(h
      • CAS號:
      • 10040-45-6
      • 分子式:
      • C18H13NO8S2.2Na
      • 分子量:
      • 481.407
      • 核磁/質譜:
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      產品介紹

      參考文獻

      質檢證書(COA)

      摩爾濃度計算器

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      • 提示:詳情請下載說明書。
      • 產品描述: Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
      • 體內研究: Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa.Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study.Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal.
      • 參考文獻:
        1.Geboes K, et al. Pharmacology, 1993, 47 Suppl 1, 187-195. 2.Fioramonti J, et al. Pharmacology, 1993, 47 Suppl 1, 155-161. 3.Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325. 4.Tzavella K, et al. Eur J Gastroenterol Hepatol, 1995, 7(1), 13-20.
      • 溶解性: Ethanol:3  mg/mL  (6.23  mM)    DMSO:89  mg/mL  (184.9  mM)    H2O:88  mg/mL  (182.8  mM)
      • 保存條件: -20℃
      • 配置溶液濃度參考:
        1mg 5mg 10mg
        1 mM 2.077 ml 10.386 ml 20.772 ml
        5 mM 0.415 ml 2.077 ml 4.154 ml
        10 mM 0.208 ml 1.039 ml 2.077 ml
        50 mM 0.042 ml 0.208 ml 0.415 ml
      • 注意:部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
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