<track id="hnued"></track>
    <legend id="hnued"></legend>
    <acronym id="hnued"></acronym>
    1. <span id="hnued"><sup id="hnued"></sup></span>

      歡迎光臨源葉生物,登錄 | 注冊 |
      當前位置: 首頁 > 小分子化合物 > 小分子抑制劑 > Rabusertib

      所有商品分類

      瀏覽歷史

      S51755

      Rabusertib

      MedMol 98%
      • 英文名:
      • Rabusertib
      • 別名:
      • Rabusertib;LY2603618;IC-83
      • CAS號:
      • 911222-45-2
      • 分子式:
      • C18H22BrN5O3
      • 分子量:
      • 436.3
      貨號產品規格市場價(RMB)您的折扣價(RMB)庫存(上海) 北京 武漢 南京 數量計量單位 加入購物車...
      S51755-5mg 98% ¥480.00元 ¥480.00元 預計交期:3-5天 0 0 0 EA 加入購物車
      S51755-10mg 98% ¥780.00元 ¥780.00元 預計交期:3-5天 0 0 0 EA 加入購物車
      S51755-25mg 98% ¥1560.00元 ¥1560.00元 預計交期:3-5天 0 0 0 EA 加入購物車
      S51755-100mg 98% ¥4680.00元 ¥4680.00元 預計交期:3-5天 0 0 0 EA 加入購物車
      大包裝詢價

      提交您的電話號碼并同意《個人信息授權與保護申明》,到貨后將短信提示。
      提交

      產品介紹

      參考文獻

      質檢證書(COA)

      摩爾濃度計算器

      相關產品

      • 產品描述:

        Rabusertib (LY2603618) 是一種有效的選擇性的 Chk1 抑制劑,IC50 為 7 nM。

      • 靶點: Chk1:7 nM (IC50);Chk2:12000 nM (IC50);PDK1:893 nM (IC50)
      • 體外研究: Rabusertib (LY2603618) is a highly effective inhibitor of multiple aspects of Chk1 biology. Rabusertib (LY2603618) is tested against a panel of 51 diverse protein kinases in vitro. With an IC50 of 7 nM for Chk1, Rabusertib (LY2603618) is approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated (PDK1, IC50=893 nM, others >1000 nM). Rabusertib (LY2603618) effectively reduced Chk1 autophosphorylation with an EC50 of 430 nM. Inhibition of Chk1 by Rabusertib (LY2603618) also effectively abrogated the G2/M DNA damage checkpoint in cells treated with DNA damaging agents. Treatment of cells with Rabusertib (LY2603618) produced a cellular phenotype similar to that reported for depletion of Chk1 by RNAi. Inhibition of intracellular Chk1 by Rabusertib (LY2603618) results in impaired DNA synthesis, elevated H2A.X phosphorylation indicative of DNA damage and premature entry into mitosis. Treatments of the SK-N-BE(2) cells with variable concentrations of Rabusertib (LY2603618) results in dose-dependent inhibition of cell growth determined by MTT assays with an IC50 of 10.81 μM
      • 體內研究: Mice bearing Calu-6 xenografts are treated with 150 mg/kg (IP) Gemcitabine and a single simultaneous 200 mg/kg oral dose of Rabusertib (LY2603618). 200 mg/kg of Rabusertib (LY2603618) is sufficient to inhibit 85 % of Chk1 autophosphorylation in vivo at 2 h. Rabusertib (LY2603618) effectively reduces Gemcitabine-induced phosphorylation on Tlk serine 695 as well, supporting the cited report with a selective chemical inhibitor of Chk1.
      • 參考文獻:
        1. King C, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26.

        2. Wang G, et al. Panobinostat synergistically enhances the cytotoxic effects of cisplatin, doxorubicin or etoposide on high-risk neuroblastoma cells. PLoS One. 2013 Sep 30;8(9):e76662.
      • 溶解性: soluble  in  DMSO
      • 保存條件: -20℃
      • 配置溶液濃度參考:
        1mg 5mg 10mg
        1 mM 2.292 ml 11.46 ml 22.92 ml
        5 mM 0.458 ml 2.292 ml 4.584 ml
        10 mM 0.229 ml 1.146 ml 2.292 ml
        50 mM 0.046 ml 0.229 ml 0.458 ml
      • 注意:部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
      輸入產品批號:

      本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系,公式為:


      質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子量 (g/mol)


      • =
        *
        *


      源葉所有產品僅用作科學研究,銷售產品行為均適用于我司網上所列通用銷售條款。
      国产成人无码精品久久久露脸_人妻无码午夜福利av在线_日日狠狠久久偷偷色综合96蜜桃_色狠狠久久av五月综合水蜜桃

        <track id="hnued"></track>
        <legend id="hnued"></legend>
        <acronym id="hnued"></acronym>
        1. <span id="hnued"><sup id="hnued"></sup></span>